"It's a hard three letters to absorb. It's a turning point in one's life," the 50-year-old actor said.
Sheen said he made the announcement to end a smear campaign and extortion efforts.
"I have to put a stop to this onslaught, this barrage of attacks and of sub-truths and very harmful and mercurial stories that are about me, threatening the health of so many others that couldn't be further from the truth," he said.
Sheen also said that he's trusted the diagnosis with people he thought he could confide in, but has paid out upwards of $10 million to keep the illness a secret.
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